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Braz. j. infect. dis ; 14(3): 291-293, May-June 2010. ilus
Article in English | LILACS | ID: lil-556844

ABSTRACT

Acute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from initial infection to development of clinical AIDS is approximately 8-10 years, but it is variable among individuals and depends on a complex interaction between virus and host. Here we describe an extraordinary case of a man who developed Pneumocisits jiroveci pneumonia within one month after sexual exposure to HIV-1, and then presented with 3 consecutive CD4 counts bellow 200 cells/mm³ within 3 months, with no other opportunistic disease. Although antiretroviral therapy (AZT+3TC+ATZ/r) was started, with full adherence of the patient, and genotyping indicating no primary antiretroviral resistance mutations, he required more than six months to have a CD4 restoration to levels above 200 cells/mm³ and 10 months to HIV-RNA to become undetectable.


Subject(s)
Adult , Humans , Male , AIDS-Related Opportunistic Infections/pathology , Anti-HIV Agents/therapeutic use , Disease Progression , Pneumocystis carinii , Pneumonia, Pneumocystis/pathology , Acute Disease , AIDS-Related Opportunistic Infections/drug therapy , HIV Infections/drug therapy , HIV Infections/pathology , Viral Load
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